Louisiana State University Department of Biological Sciences
DowellResearch Group
Publications

Transcriptome reallocation during infection reshapes synonymous codon demand in Botrytis cinerea

Overview

Reanalysis of 39 RNA-sequencing libraries across three host systems shows how shifts in gene expression during infection change the synonymous codons represented in the Botrytis cinerea transcript pool. Early changes align across studies, while later trajectories diverge, providing a basis for testing consequences for RNA stability and translation.

Read version 1 on bioRxiv. Posted November 6, 2026; this preprint has not been peer reviewed.

Figure 2: fungal codon-demand trajectories across tomato, Arabidopsis, and moss infection series, temporal effect sizes, and similarity of early changes across host systems.
Figure 2. Fungal synonymous-codon demand changes across three host systems. Panels show (a) variation among fungal transcript profiles over infection time, (b) within-study temporal effect sizes, and (c) similarity of changes over the aligned 16–24-hour interval. Colors identify the host infection series; all profiles are fungal.
Reproduced without alteration from Dowell, Pradhan & Madrigal (2026), bioRxiv preprint, Figure 2, licensed CC BY-NC 4.0. View full size.